Title: Transition Metal Free alpha-C-Alkylation of Ketones Using Secondary Alcohols - data
Citation
Dambatta M (2020). Transition Metal Free alpha-C-Alkylation of Ketones Using Secondary Alcohols - data. Cardiff University. https://doi.org/10.17035/d.2020.0116098795
This data is not currently available because: Intent to publish project results
Access Rights: Data is provided under a Creative Commons Attribution (CC BY 4.0) licence
Access Method: Click to email a request for this data to opendata@cardiff.ac.uk
Dataset Details
Publisher: Cardiff University
Date (year) of data becoming publicly available: 2020
Data format: .txt, .inmr, .info, .par, .xml, .pdf, .temp, .back, .jpg, .ispd
Software Required: An appropriate NMR processing software is required for raw NMR data files
Estimated total storage size of dataset: Less than 1 gigabyte
DOI : 10.17035/d.2020.0116098795
DOI URL: http://doi.org/10.17035/d.2020.0116098795
Related URL: http://blogs.cardiff.ac.uk/themorrillgroup/
A base-mediated a-C-alkylation of ketones with secondary alcohols has been developed. This transition metal free approach employs KOt-Bu as the base and exhibits a broad scope, allowing a range of commodity aliphatic secondary alcohols and 1-arylethanols to be employed as alkylating agents. Aryl methyl ketones undergo selective mono-a-C-alkylation in high isolated yields (23 examples, 65% average yield). Analysis of reaction products from this methodology resulted in the following data: 1H, 19F and 13C NMR raw data files IR spectra High-Resolution Mass Spectrography spectra.
Description
Related Projects
- Catalytic Functionalization of Alcohols (01/04/2018 - 31/03/2021)
