Teitl: Transition Metal Free alpha-C-Alkylation of Ketones Using Secondary Alcohols - data

Dyfyniad
Dambatta M (2020). Transition Metal Free alpha-C-Alkylation of Ketones Using Secondary Alcohols - data. Cardiff University. http://doi.org/10.17035/d.2020.0116098795


Nid yw'r data hwn ar gael ar hyn o bryd oherwydd: Bwriad i gyhoeddi canlyniadau prosiect
Dull Mynediad: I anfon cais i gael y data hwn, ebostiwch opendata@caerdydd.ac.uk

Crewyr y Set Ddata o Brifysgol Caerdydd

Manylion y Set Ddata
Cyhoeddwr: Cardiff University
Dyddiad (y flwyddyn) pryd y daeth y data ar gael i'r cyhoedd: 2020
Fformat y data: .txt, .inmr, .info, .par, .xml, .pdf, .temp, .back, .jpg, .ispd
Meddalwedd ofynnol: An appropriate NMR processing software is required for raw NMR data files
Amcangyfrif o gyfanswm maint storio'r set ddata: Llai nag 1 gigabeit
DOI: 10.17035/d.2020.0116098795

Disgrifiad

A base-mediated a-C-alkylation of ketones with secondary alcohols has been developed. This transition metal free approach employs KOt-Bu as the base and exhibits a broad scope, allowing a range of commodity aliphatic secondary alcohols and 1-arylethanols to be employed as alkylating agents. Aryl methyl ketones undergo selective mono-a-C-alkylation in high isolated yields (23 examples, 65% average yield).

Analysis of reaction products from this methodology resulted in the following data:

1H, 19F and 13C NMR raw data files

IR spectra

High-Resolution Mass Spectrography spectra.



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Prosiectau Cysylltiedig
Catalytic Functionalization of Alcohols (01.04.2018 - 31.03.2021)

Diweddarwyd y tro diwethaf ar 2020-09-09 am 10:48