Title: Transition Metal Free alpha-C-Alkylation of Ketones Using Secondary Alcohols - data


Citation
Dambatta M (2020). Transition Metal Free alpha-C-Alkylation of Ketones Using Secondary Alcohols - data. Cardiff University. http://doi.org/10.17035/d.2020.0116098795



This data is not currently available because: Intent to publish project results

Access Method: Click to email a request for this data to opendata@cardiff.ac.uk


Cardiff University Dataset Creators


Dataset Details

Publisher: Cardiff University

Date (year) of data becoming publicly available: 2020

Data format: .txt, .inmr, .info, .par, .xml, .pdf, .temp, .back, .jpg, .ispd

Software Required: An appropriate NMR processing software is required for raw NMR data files

Estimated total storage size of dataset: Less than 1 gigabyte

DOI : 10.17035/d.2020.0116098795

DOI URL: http://doi.org/10.17035/d.2020.0116098795

Related URL: http://blogs.cardiff.ac.uk/themorrillgroup/


Description

A base-mediated a-C-alkylation of ketones with secondary alcohols has been developed. This transition metal free approach employs KOt-Bu as the base and exhibits a broad scope, allowing a range of commodity aliphatic secondary alcohols and 1-arylethanols to be employed as alkylating agents. Aryl methyl ketones undergo selective mono-a-C-alkylation in high isolated yields (23 examples, 65% average yield).

Analysis of reaction products from this methodology resulted in the following data:

1H, 19F and 13C NMR raw data files

IR spectra

High-Resolution Mass Spectrography spectra.


Research Areas

Related Projects

Last updated on 2021-21-04 at 14:00