Title: Transition Metal Free alpha-C-Alkylation of Ketones Using Secondary Alcohols - data

Citation
Dambatta M (2020). Transition Metal Free alpha-C-Alkylation of Ketones Using Secondary Alcohols - data. Cardiff University. http://doi.org/10.17035/d.2020.0116098795


This data is not currently available because: Intent to publish project results
Access Method: Click to email a request for this data to opendata@cardiff.ac.uk

Cardiff University Dataset Creators

Dataset Details
Publisher: Cardiff University
Date (year) of data becoming publicly available: 2020
Data format: .txt, .inmr, .info, .par, .xml, .pdf, .temp, .back, .jpg, .ispd
Software Required: An appropriate NMR processing software is required for raw NMR data files
Estimated total storage size of dataset: Less than 1 gigabyte
DOI: 10.17035/d.2020.0116098795

Description

A base-mediated a-C-alkylation of ketones with secondary alcohols has been developed. This transition metal free approach employs KOt-Bu as the base and exhibits a broad scope, allowing a range of commodity aliphatic secondary alcohols and 1-arylethanols to be employed as alkylating agents. Aryl methyl ketones undergo selective mono-a-C-alkylation in high isolated yields (23 examples, 65% average yield).

Analysis of reaction products from this methodology resulted in the following data:

1H, 19F and 13C NMR raw data files

IR spectra

High-Resolution Mass Spectrography spectra.



Research Areas

Related Projects
Catalytic Functionalization of Alcohols (01/04/2018 - 31/03/2021)

Last updated on 2020-09-09 at 10:48

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