Teitl: Measurement of oxygen extraction fraction (OEF): an optimised BOLD signal model for use with hypercapnic and hyperoxic calibration

Dyfyniad
Merola A, Wise RG, Germuska MA (2016). Measurement of oxygen extraction fraction (OEF): an optimised BOLD signal model for use with hypercapnic and hyperoxic calibration. Cardiff University. http://doi.org/10.17035/d.2015.100127


Hawliau Mynediad: Gall data fod ar gael yn rhad ac am ddim yn amodol ar briodoli
Dull Mynediad: I anfon cais i gael y data hwn, ebostiwch opendata@caerdydd.ac.uk

Crewyr y Set Ddata o Brifysgol Caerdydd

Manylion y Set Ddata
Cyhoeddwr: Cardiff University
Dyddiad (y flwyddyn) pryd y daeth y data ar gael i'r cyhoedd: 2016
Math o ddata: MATLAB functions and scripts
Fformat y data: .m
Meddalwedd ofynnol: MATLAB
Maint y ffeil ddata: 50 Kilobytes
Nifer y ffeiliau yn y set ddata: 5
DOI: 10.17035/d.2015.100127

Disgrifiad

Several techniques have been proposed to estimate relative changes in cerebral metabolic rate of oxygen consumption (CMRO2) by exploiting combined BOLD fMRI and cerebral blood flow data in conjunction with hypercapnic or hyperoxic respiratory challenges. More recently, methods based on respiratory challenges that include both hypercapnia and hyperoxia have been developed to assess absolute CMRO2, an important parameter for understanding brain energetics. The aim of this project is to empirically optimise a previously presented “original calibration model” relating BOLD and blood flow signals specifically for the estimation of oxygen extraction fraction (OEF) and absolute cerebral metabolic rate of oxygen consumption (CMRO2). The data made publicly available allow to simulate a wide range of physiological conditions by varying input parameter values (baseline cerebral blood volume (CBV0), baseline cerebral blood flow (CBF0), baseline oxygen extraction fraction (OEF0) and haematocrit (Hct)). These conditions are then used to create a set of synthetic BOLD signals using a detailed BOLD signal model to reproduce experiments incorporating hypercapnic and hyperoxic respiratory challenges at 3 Tesla. From the optimisation of the calibration model for estimation of OEF and practical considerations of hypercapnic and hyperoxic respiratory challenges, a new “simplified calibration model” is established which reduces the complexity of the original calibration model by substituting the standard parameters α and β with a single parameter θ. The optimal value of θ is determined (θ =0.06) across a range of experimental respiratory challenges. The simplified calibration model gives estimates of OEF0 and absolute CMRO2 closer to the true values used to simulate the experimental data compared to those estimated using the original model incorporating literature values of α and β. Finally, an error propagation analysis demonstrates the susceptibility of the original and simplified calibration models to measurement errors and potential violations in the underlying assumptions of isometabolism. We conclude that using the simplified calibration model results in a reduced bias in OEF0 estimates across a wide range of potential respiratory challenge experimental designs.
Results derived from these data are published at http://dx.doi.org/10.1016/j.neuroimage.2016.01.021


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Diweddarwyd y tro diwethaf ar 2019-21-10 am 11:45