Teitl: Iron-catalyzed methylation using the borrowing hydrogen approach

Dyfyniad
Polidano K, Allen B, Williams J, et al. (2018). Iron-catalyzed methylation using the borrowing hydrogen approach. Cardiff University. https://doi.org/10.17035/d.2018.0051041048

Manylion y Set Ddata

Cyhoeddwr: Cardiff University

Dyddiad (y flwyddyn) pryd y daeth y data ar gael i'r cyhoedd: 2018

Fformat y data: .txt, .inmr, .info, .par, .xml, .pdf, .temp, .back, .jpg, .ispd

Meddalwedd ofynnol: An appropriate NMR processing software is required for raw NMR data files

Amcangyfrif o gyfanswm maint storio'r set ddata: Llai nag 1 gigabeit

Nifer y ffeiliau yn y set ddata: 4787

DOI : 10.17035/d.2018.0051041048

DOI URL: http://doi.org/10.17035/d.2018.0051041048

Related URL: http://blogs.cardiff.ac.uk/themorrillgroup/

Disgrifiad

A general iron-catalyzed methylation has been developed using methanol as a sustainable C1 building block. This borrowing hydrogen approach employs a Knölker-type (cyclopentadienone)iron carbonyl complex as catalyst (2 mol %) and exhibits a broad reaction scope. A variety of ketones, indoles, oxindoles, amines and sulfonamides undergo mono- or dimethylation in excellent isolated yields (>60 examples, 79% average yield).

Analysis of reaction products from this methodology resulted in the following data:

1H, 19F and 13C NMR raw data files

IR spectra

High resolution mass spectrometry spectra.

Research results based upon these data are published at http://dx.doi.org/10.1021/acscatal.8b02158