Title: Mechanochemical Activation of Zinc and Application to Negishi Cross-Coupling


Citation
Browne DL, Cao Q, Howard JL (2018). Mechanochemical Activation of Zinc and Application to Negishi Cross-Coupling. Cardiff University. http://doi.org/10.17035/d.2018.0052918729



Access Rights: Data can be made freely available subject to attribution

Access Method: Click to email a request for this data to opendata@cardiff.ac.uk


Cardiff University Dataset Creators


Dataset Details

Publisher: Cardiff University

Date (year) of data becoming publicly available: 2018

Data format: .jpg .fid

Software Required: NMR processing software such as Topspin and Mestranova

Estimated total storage size of dataset: Less than 1 gigabyte

Number of Files In Dataset: 1000

DOI : 10.17035/d.2018.0052918729

DOI URL: http://doi.org/10.17035/d.2018.0052918729

Related URL: http://www.thebrowneresearchgroup.co.uk


Description

A form independent activation of zinc, concomitant generation of organozinc species and engagement in a Negishi cross-coupling reaction via mechanochemical methods is reported. The reported method exhibits a broad substrate scope for both Csp3-Csp2andCsp2-Csp2couplings and is tolerant to many important functional groups. The method may offer broad reaching opportunities for the in situ generation and use of organometallic compounds from base metals and their subsequent engagement in synthetic reactions via mechanochemical methods.

The data here contains a selection of 1H, 13C, 19F NMR data, as well as IR, MS and any relevant chromatography information. Some files may be processed in advance and deposited and some may require access to typical processing tools for data of this type.

Research results based upon these data are published at http://doi.org/10.1002/anie.201806480


Keywords

Mechanochemistry

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Last updated on 2018-28-08 at 15:16