Title: Mechanochemical Activation of Zinc and Application to Negishi Cross-Coupling

Citation
Browne DL, Cao Q, Howard JL (2018). Mechanochemical Activation of Zinc and Application to Negishi Cross-Coupling. Cardiff University. http://doi.org/10.17035/d.2018.0052918729


Access Rights: Data can be made freely available subject to attribution
Access Method: Click to email a request for this data to opendata@cardiff.ac.uk

Cardiff University Dataset Creators

Dataset Details
Publisher: Cardiff University
Date (year) of data becoming publicly available: 2018
Data format: .jpg .fid
Software Required: NMR processing software such as Topspin and Mestranova
Estimated total storage size of dataset: Less than 1 gigabyte
Number of Files In Dataset: 1000
DOI: 10.17035/d.2018.0052918729

Description

A form independent activation of zinc, concomitant generation of organozinc species and engagement in a Negishi cross-coupling reaction via mechanochemical methods is reported. The reported method exhibits a broad substrate scope for both Csp3-Csp2andCsp2-Csp2couplings and is tolerant to many important functional groups. The method may offer broad reaching opportunities for the in situ generation and use of organometallic compounds from base metals and their subsequent engagement in synthetic reactions via mechanochemical methods.

The data here contains a selection of 1H, 13C, 19F NMR data, as well as IR, MS and any relevant chromatography information. Some files may be processed in advance and deposited and some may require access to typical processing tools for data of this type.

Research results based upon these data are published at http://doi.org/10.1002/anie.201806480



Keywords

Mechanochemistry

Related Projects

Last updated on 2018-28-08 at 15:16