Teitl: Switching Chemoselectivity: Using Mechanochemistry to Alter Reaction Kinetics

Dyfyniad
Browne DL, Howard JL, Brand MC (2018). Switching Chemoselectivity: Using Mechanochemistry to Alter Reaction Kinetics. Cardiff University. http://doi.org/10.17035/d.2018.0062874363


Hawliau Mynediad: Gall data fod ar gael yn rhad ac am ddim yn amodol ar briodoli
Dull Mynediad: I anfon cais i gael y data hwn, ebostiwch opendata@caerdydd.ac.uk

Crewyr y Set Ddata o Brifysgol Caerdydd

Manylion y Set Ddata
Cyhoeddwr: Cardiff University
Dyddiad (y flwyddyn) pryd y daeth y data ar gael i'r cyhoedd: 2018
Dyddiad dechrau creu'r data: 01.06.2017
Dyddiad gorffen creu'r data: 01.09.2018
Fformat y data: .jpg .fid
Meddalwedd ofynnol: .fid files are processed using standard NMR processing software.
Amcangyfrif o gyfanswm maint storio'r set ddata: Llai na 100 megabeit
DOI: 10.17035/d.2018.0062874363

Disgrifiad

The data here contains a selection of 1H, 13C, 19F NMR data, as well as IR, MS and any relevant chromatography information. Some files may be processed in advance and deposited and some may require access to typical processing tools for data of this type.
Abstract: A reaction manifold has been discovered in which the chemoselectivity can be altered by switching between neat milling and liquid assisted grinding (LAG) with polar additives. After investigation of the reaction mechanism, it has been established that this switching in reaction pathway is due to the neat mechanochemical conditions exhibiting different kinetics for a key step in the transformation. This proof of concept study demonstrates that mechanochemistry can be used to trap the kinetic product of a reaction. It is envisaged that, if this concept can be successfully applied to other transformations, novel synthetic processes could be discovered and known reaction pathways perturbed or diverted.



Allweddeiriau

Mechanochemistry

Meysydd Ymchwil

Prosiectau Cysylltiedig

Diweddarwyd y tro diwethaf ar 2018-12-11 am 12:15