Title: Manganese-Catalyzed N-Alkylation of Sulfonamides Using Alcohols

Citation
Reed-Berendt BG, Morrill LC (2019). Manganese-Catalyzed N-Alkylation of Sulfonamides Using Alcohols. Cardiff University. http://doi.org/10.17035/d.2019.0069100566


Access Rights: Data can be made freely available subject to attribution
Access Method: Click to email a request for this data to opendata@cardiff.ac.uk

Cardiff University Dataset Creators

Dataset Details
Publisher: Cardiff University
Date (year) of data becoming publicly available: 2019
Data format: .txt, .inmr, .info, .par, .xml, .pdf, .temp, .back, .jpg, .ispd
Software Required: An appropriate NMR processing software is required for raw NMR data files
Estimated total storage size of dataset: Less than 1 gigabyte
Number of Files In Dataset: 2773
DOI: 10.17035/d.2019.0069100566

Description

An efficient manganese-catalyzed N-alkylation of sulfonamides has been developed. This borrowing hydrogen approach employs a well-defined and bench stable Mn(I) PNP pincer precatalyst, allowing benzylic and simple primary aliphatic alcohols to be employed as alkylating agents. A diverse range of aryl and alkyl sulfonamides undergoes mono-N-alkylation in excellent isolated yields (32 examples, 85% average yield).

Analysis of reaction products from this methodology resulted in the following data:

1H, 19F and 13C NMR raw data files

IR spectra

High-Resolution Mass Spectrography spectra.

Research results based upon these data are published at http://doi.org/10.1021/acs.joc.9b00203


Research Areas

Related Projects
Homogeneous hydrogen transfer catalysis (01/10/2016 - 30/09/2019)

Last updated on 2019-02-07 at 11:10