Title: Manganese-Catalyzed N-Alkylation of Sulfonamides Using Alcohols


Citation
Reed-Berendt BG, Morrill LC (2019). Manganese-Catalyzed N-Alkylation of Sulfonamides Using Alcohols. Cardiff University. http://doi.org/10.17035/d.2019.0069100566



Access Rights: Data can be made freely available subject to attribution

Access Method: Click to email a request for this data to opendata@cardiff.ac.uk


Cardiff University Dataset Creators


Dataset Details

Publisher: Cardiff University

Date (year) of data becoming publicly available: 2019

Data format: .txt, .inmr, .info, .par, .xml, .pdf, .temp, .back, .jpg, .ispd

Software Required: An appropriate NMR processing software is required for raw NMR data files

Estimated total storage size of dataset: Less than 1 gigabyte

Number of Files In Dataset: 2773

DOI : 10.17035/d.2019.0069100566

DOI URL: http://doi.org/10.17035/d.2019.0069100566

Related URL: http://blogs.cardiff.ac.uk/themorrillgroup/


Description

An efficient manganese-catalyzed N-alkylation of sulfonamides has been developed. This borrowing hydrogen approach employs a well-defined and bench stable Mn(I) PNP pincer precatalyst, allowing benzylic and simple primary aliphatic alcohols to be employed as alkylating agents. A diverse range of aryl and alkyl sulfonamides undergoes mono-N-alkylation in excellent isolated yields (32 examples, 85% average yield).

Analysis of reaction products from this methodology resulted in the following data:

1H, 19F and 13C NMR raw data files

IR spectra

High-Resolution Mass Spectrography spectra.

Research results based upon these data are published at http://doi.org/10.1021/acs.joc.9b00203


Research Areas

Related Projects

Last updated on 2019-02-07 at 11:10