Title: Iron-Catalyzed Borrowing Hydrogen C-Alkylation of Oxindoles Using Alcohols

Citation
Dambatta MM, Polidano K (2019). Iron-Catalyzed Borrowing Hydrogen C-Alkylation of Oxindoles Using Alcohols. Cardiff University. http://doi.org/10.17035/d.2019.0072633299


Access Rights: Data can be made freely available subject to attribution
Access Method: Click to email a request for this data to opendata@cardiff.ac.uk

Cardiff University Dataset Creators

Dataset Details
Publisher: Cardiff University
Date (year) of data becoming publicly available: 2019
Data format: .txt, .inmr, .info, .par, .xml, .pdf, .temp, .back, .jpg, .ispd
Software Required: An appropriate NMR processing software is required for raw NMR data files
Estimated total storage size of dataset: Less than 1 gigabyte
Number of Files In Dataset: 2518
DOI: 10.17035/d.2019.0072633299

Description

A general and efficient iron‐catalyzed C‐alkylation of oxindoles has been developed. This borrowing hydrogen approach employs a (cyclopentadienone)iron carbonyl complex (2 mol %) and exhibits a broad reaction scope, allowing benzylic and simple primary and secondary aliphatic alcohols to be employed as alkylating agents. A variety of oxindoles undergo selective mono‐C(3)‐alkylation in good to excellent isolated yields (28 examples, 50‐92% yield, 79% average yield).

Analysis of reaction products from this methodology resulted in the following data:

1H, 19F and 13C NMR raw data files

IR spectra

High-Resolution Mass Spectrography spectra.

Research results based upon these data are puiblished at http://doi.org/10.1002/cssc.201900799


Research Areas

Related Projects
Homogeneous hydrogen transfer catalysis (01/10/2016 - 30/09/2019)

Last updated on 2019-26-11 at 14:22