Title: A Ball-Milling Enabled Reformatsky Reaction
Citation
Cao Q, Stark RT, Fallis IA, et al. (2019). A Ball-Milling Enabled Reformatsky Reaction. Cardiff University. http://doi.org/10.17035/d.2019.0075438608
Access Rights: Data is provided under a Creative Commons Attribution (CC BY 4.0) licence
Access Method: Click to email a request for this data to opendata@cardiff.ac.uk
Dataset Details
Publisher: Cardiff University
Date (year) of data becoming publicly available: 2019
Coverage start date: 01/06/2017
Coverage end date: 05/01/2019
Data format: .jpg .fid
Software Required: .fid files are processed using standard NMR processing software.
DOI : 10.17035/d.2019.0075438608
DOI URL: http://doi.org/10.17035/d.2019.0075438608
Related URL: https://onlinelibrary.wiley.com/doi/10.1002/cssc.201900886
The data here contains a selection of 1H, 13C, 19F NMR data, as well as IR, MS and any relevant chromatography information. Some files may be processed in advance and deposited and some may require access to typical processing tools for data of this type. Research results based upone these data are published at http://doi.org/10.1002/cssc.201900886
Description
Abstract: An operationally simple one‐jar one‐step mechanochemical Reformatsky reaction using in situ generated organozinc intermediates under neat grinding conditions has been developed. Notable features are that this reaction protocol requires no solvent, no inert gases and no pre‐activation of the bulk zinc source. The developed process is demonstrated to have good substrate scope (39‐82% yield), and is effective irrespective of the morphology of the zinc source.
Keywords
Mechanochemistry, Organozinc
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