Title: Iron-Catalyzed Borrowing-Hydrogen β‐C(sp3)‐Methylation of Alcohols

Citation
Polidano K, Morrill LC (2019). Iron-Catalyzed Borrowing-Hydrogen β‐C(sp3)‐Methylation of Alcohols. Cardiff University. http://doi.org/10.17035/d.2019.0082983146


This data is not currently available because: Intent to publish project results
Access Method: Click to email a request for this data to opendata@cardiff.ac.uk

Cardiff University Dataset Creators

Dataset Details
Publisher: Cardiff University
Date (year) of data becoming publicly available: 2019
Data format: .txt, .inmr, .info, .par, .xml, .pdf, .temp, .back, .jpg, .ispd
Software Required: An appropriate NMR processing software is required for raw NMR data files
Estimated total storage size of dataset: Less than 1 gigabyte
Number of Files In Dataset: 3271
DOI: 10.17035/d.2019.0082983146

Description

Herein we report the iron-catalyzed b-C(sp3)-methylation of primary alcohols using methanol as a C1 building block. This borrowing hydrogen approach employs a well-defined bench stable (cyclopentadienone)iron(0) carbonyl complex as precatalyst (5 mol %) and enables a diverse selection of substituted 2-arylethanols to undergo b-C(sp3)-methylation in good isolated yields (24 examples, 65% average yield).

Analysis of reaction products from this methodology resulted in the following data:

1H, 19F and 13C NMR raw data files

IR spectra

High resolution mass spectrometry spectra.    

Research results based upon these data are published at http://doi.org/10.1021/acscatal.9b02461.


Related Projects
Homogeneous hydrogen transfer catalysis (01/10/2016 - 30/09/2019)

Last updated on 2019-19-12 at 12:38