Title: Iron-Catalyzed Borrowing-Hydrogen β‐C(sp3)‐Methylation of Alcohols

Polidano K, Morrill LC (2019). Iron-Catalyzed Borrowing-Hydrogen β‐C(sp3)‐Methylation of Alcohols. Cardiff University. http://doi.org/10.17035/d.2019.0082983146

Access Rights: Data is provided under a Creative Commons Attribution (CC BY 4.0) licence
Access Method: Click to email a request for this data to opendata@cardiff.ac.uk

Cardiff University Dataset Creators

Dataset Details
Publisher: Cardiff University
Date (year) of data becoming publicly available: 2019
Data format: .txt, .inmr, .info, .par, .xml, .pdf, .temp, .back, .jpg, .ispd
Software Required: An appropriate NMR processing software is required for raw NMR data files
Estimated total storage size of dataset: Less than 1 gigabyte
Number of Files In Dataset: 3271
DOI: 10.17035/d.2019.0082983146


Herein we report the iron-catalyzed b-C(sp3)-methylation of primary alcohols using methanol as a C1 building block. This borrowing hydrogen approach employs a well-defined bench stable (cyclopentadienone)iron(0) carbonyl complex as precatalyst (5 mol %) and enables a diverse selection of substituted 2-arylethanols to undergo b-C(sp3)-methylation in good isolated yields (24 examples, 65% average yield).

Analysis of reaction products from this methodology resulted in the following data:

1H, 19F and 13C NMR raw data files

IR spectra

High resolution mass spectrometry spectra.    

Research results based upon these data are published at http://doi.org/10.1021/acscatal.9b02461.

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Last updated on 2020-23-11 at 14:56