Dr Mariah Lelos
Projects as PI
- Advancing a stem cell therapy for Huntington’s disease towards the clinic (01/01/2024 - 31/05/2024)
- A NON-GLP Efficacy Study of ANPD001 from four different donors implanted to the brain of unilateral 6-OHDA medial forebrain bundle lesioned immuno-suppressed adult female lister-hooded (01/10/2021 - 31/12/2022)
- Determining the functional efficacy of centrally-administered novel AAV viral vector therapies for Parkinson's disease (15/02/2018 - 31/08/2018)
- Elucidating the function of the dopaminergic midbrain-claustrum projection in the healthy brain and in Parkinson's disease. (01/10/2024 - 30/09/2027)
- Establishment of nude Parkinsonian rats forassessment of GBA hiPSC-derived grafts (01/09/2022 - 28/02/2023)
Projects as Co-Investigator
- 18F-Difluoromethylation: The Missing link in radiochemistry for positron emission tomography (01/04/2021 - 31/03/2024)
- A study to evaluate the potential of vectors administered by isolated limb infusion to transduce production and secretion of L-dopa by striated muscle (01/05/2018 - 28/02/2019)
- Cell therapy for Huntington's disease, addressing critical knowledge gaps (01/01/2021 - 31/12/2025)
- Developing a CRISPR/Cas9 nickase approach for in vivo correction of the Huntington’s disease mutation (01/03/2023 - 28/02/2025)
- Ex vivo cultures of fresh human brain tissues for testing the safety and efficacy of gene editing approaches for HD (01/11/2021 - 31/01/2024)