Title: Development and evaluation of selective allosteric calpain-1 inhibitors
Funder
Engineering and Physical Sciences Research Council
Principal Investigator
Co-Investigators
Allemann, Rudolf
Miller, David
Project Details
Start date: 01/01/2016
End date: 31/12/2019
Abstract
Exploring and
evaluating the development diselenoacrylates as redox stable allosteric
calpain-1 inhibitors based upon previous α-mercaptoacrylate
analogues, as well as the structure guided computational design and
validation of novel calpain-1 inhibitors.
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